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NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro).
No product in this corpus aims at NR2F2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA NR2F2: RNA low tissue specificity; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas NR2F2 tissue; Open Targets ENSG00000185551 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Ladias J.A.A. et al, Science, 1991, "Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily". Source.
Sources: HGNC HGNC:7976 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P24468 (protein name, function text, keywords and locations (REST API)); CIViC gene NR2F2 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development. Location: Nucleus (UniProt). Locus 15q26.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NR2F2" OR ABSTRACT:"NR2F2" OR TITLE:"nuclear receptor subfamily 2 group F member 2" OR ABSTRACT:"nuclear receptor subfamily 2 group F member 2" OR TITLE:"COUP transcription factor 2" OR ABSTRACT:"COUP transcription factor 2" OR TITLE:"COUP-TFII" OR ABSTRACT:"COUP-TFII" OR TITLE:"COUPTFB" OR ABSTRACT:"COUPTFB" OR TITLE:"SVP40" OR ABSTRACT:"SVP40") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NR2F2, not a curated reading list.