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NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin and Fluorouracil.
In plain words · NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Location: Membrane (UniProt).
No product in this corpus aims at NPTXR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA NPTXR: RNA tissue enriched (brain 179 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas NPTXR tissue; Open Targets ENSG00000221890 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Dunham et al, Nature, 1999, "The DNA sequence of human chromosome 22". Source.
Sources: HGNC HGNC:7954 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95502 (protein name, function text, keywords and locations (REST API)); CIViC gene NPTXR (1 evidence items, 0 assertions, 1 variants; diseases: Stomach Carcinoma (GraphQL API, CC0))
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Location: Membrane (UniProt). Locus 22q13.1 (HGNC).
RNA: tissue enriched (brain 179 nTPM), detected in many normal tissues.
No normal tissue stained high; medium in Cerebral cortex.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NPTXR" OR ABSTRACT:"NPTXR" OR TITLE:"neuronal pentraxin receptor" OR ABSTRACT:"neuronal pentraxin receptor" OR TITLE:"Neuronal pentraxin receptor" OR ABSTRACT:"Neuronal pentraxin receptor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NPTXR, not a curated reading list.