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NOTCH3 (Neurogenic locus notch homolog protein 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Tarextumab.
In plain words · NOTCH3 (Neurogenic locus notch homolog protein 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
NOTCH3 (Neurogenic locus notch homolog protein 3) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
No product in this corpus aims at NOTCH3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA NOTCH3: RNA tissue enhanced (blood vessel 201 nTPM); high antibody staining in 3 normal tissues; highest cancer staining carcinoid (2 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Pancreatic ductal adenocarcinoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (myofibromatosis, infantile, 2). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas NOTCH3 tissue; Open Targets ENSG00000074181 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Joutel et al, Nature, 1996, "Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia". Source.
Sources: HGNC HGNC:7883 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UM47 (protein name, function text, keywords and locations (REST API)); CIViC gene NOTCH3 (2 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Cancer, Rectum Cancer (GraphQL API, CC0))
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Location: Cell membrane; Nucleus (UniProt). Locus 19p13.12 (HGNC).
RNA: tissue enhanced (blood vessel 201 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Bone marrow, Breast, Cerebellum, Cerebral cortex, Cervix, Colon, Duodenum.
Medium only: head and neck cancer, liver cancer, lung cancer, melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NOTCH3" OR ABSTRACT:"NOTCH3" OR TITLE:"notch receptor 3" OR ABSTRACT:"notch receptor 3" OR TITLE:"Neurogenic locus notch homolog protein 3" OR ABSTRACT:"Neurogenic locus notch homolog protein 3" OR TITLE:"CASIL" OR ABSTRACT:"CASIL" OR TITLE:"CADASIL" OR ABSTRACT:"CADASIL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NOTCH3, not a curated reading list.