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NFKBIZ (NF-kappa-B inhibitor zeta) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · NFKBIZ (NF-kappa-B inhibitor zeta) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
NFKBIZ (NF-kappa-B inhibitor zeta) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation.
No product in this corpus aims at NFKBIZ yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA NFKBIZ: RNA tissue enriched (bone marrow 384 nTPM); blood lineage group enriched (granulocytes 25 nTPM, monocytes 34 nTPM); high antibody staining in 3 normal tissues. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas NFKBIZ tissue; Open Targets ENSG00000144802 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Ochiai et al, 2000, "Human MAIL: an inflammation-associated gene that is induced by lipopolysaccharide in leukocytes". Source.
Sources: HGNC HGNC:29805 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BYH8 (protein name, function text, keywords and locations (REST API)); CIViC gene NFKBIZ (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Location: Nucleus (UniProt). Locus 3q12.3 (HGNC).
RNA: tissue enriched (bone marrow 384 nTPM), detected in all normal tissues. Blood: group enriched (granulocytes 25 nTPM, monocytes 34 nTPM).
Medium: Lung.
No cancer stained high; medium in cervical cancer, colorectal cancer, head and neck cancer, lung cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NFKBIZ" OR ABSTRACT:"NFKBIZ" OR TITLE:"NFKB inhibitor zeta" OR ABSTRACT:"NFKB inhibitor zeta" OR TITLE:"NF-kappa-B inhibitor zeta" OR ABSTRACT:"NF-kappa-B inhibitor zeta" OR TITLE:"FLJ34463" OR ABSTRACT:"FLJ34463") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NFKBIZ, not a curated reading list.