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NFATC2 (Nuclear factor of activated T-cells, cytoplasmic 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Breast cancer, Skin cancer and 3 more.
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signalling pathway. Is involved in the negative regulation of chondrogenesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.97, animal model 0.52, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma, Rectal Adenocarcinoma.
In plain words · NFATC2 (Nuclear factor of activated T-cells, cytoplasmic 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Breast cancer, Skin cancer and 3 more.
NFATC2 (Nuclear factor of activated T-cells, cytoplasmic 2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Breast cancer, Skin cancer and 3 more.
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signalling pathway.
No product in this corpus aims at NFATC2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Luo et al, Mol. Cell. Biol, 1996, "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes". Source.
Sources: HGNC HGNC:7776 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13469 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101096 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: colorectal cancer 0.52, gastric cancer 0.52, skin cancer 0.54, breast cancer 0.56 (GraphQL API, CC0)); IntOGen NFATC2 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signalling pathway. Is involved in the negative regulation of chondrogenesis. Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signalling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signalling and activation of NFAT-dependent transcriptional responses. Location: Cytoplasm; Nucleus (UniProt). Locus 20q13.2 (HGNC).
Query for this target: (TITLE:"NFATC2" OR ABSTRACT:"NFATC2" OR TITLE:"nuclear factor of activated T cells 2" OR ABSTRACT:"nuclear factor of activated T cells 2" OR TITLE:"Nuclear factor of activated T-cells, cytoplasmic 2" OR ABSTRACT:"Nuclear factor of activated T-cells, cytoplasmic 2" OR TITLE:"NF-ATP" OR ABSTRACT:"NF-ATP" OR TITLE:"NFATp" OR ABSTRACT:"NFATp" OR TITLE:"NFAT1" OR ABSTRACT:"NFAT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NFATC2, not a curated reading list.