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NEK10 (Serine/threonine-protein kinase Nek10) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.37, genetic association 0.67).
In plain words · NEK10 (Serine/threonine-protein kinase Nek10) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
NEK10 (Serine/threonine-protein kinase Nek10) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation.
No product in this corpus aims at NEK10 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:18592 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZWH5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163491 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0))
Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport. Locus 3p24.1 (HGNC).
Query for this target: (TITLE:"NEK10" OR ABSTRACT:"NEK10" OR TITLE:"NIMA related kinase 10" OR ABSTRACT:"NIMA related kinase 10" OR TITLE:"Serine/threonine-protein kinase Nek10" OR ABSTRACT:"Serine/threonine-protein kinase Nek10" OR TITLE:"FLJ32685" OR ABSTRACT:"FLJ32685") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NEK10, not a curated reading list.