Loading
NEIL1 (Endonuclease 8-like 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidised pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.89, animal model 0.39, genetic association 0.08).
In plain words · NEIL1 (Endonuclease 8-like 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
NEIL1 (Endonuclease 8-like 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases.
No product in this corpus aims at NEIL1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2002. Earliest sequence paper UniProt cites for the protein: Takao et al, J. Biol. Chem, 2002, "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue". Source.
Sources: HGNC HGNC:18448 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96FI4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140398 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidised pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Chromosome (UniProt). Locus 15q24.2 (HGNC).
Query for this target: (TITLE:"NEIL1" OR ABSTRACT:"NEIL1" OR TITLE:"nei like DNA glycosylase 1" OR ABSTRACT:"nei like DNA glycosylase 1" OR TITLE:"Endonuclease 8-like 1" OR ABSTRACT:"Endonuclease 8-like 1" OR TITLE:"FLJ22402" OR ABSTRACT:"FLJ22402" OR TITLE:"hFPG1" OR ABSTRACT:"hFPG1" OR TITLE:"NEI1" OR ABSTRACT:"NEI1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NEIL1, not a curated reading list.