Loading
NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration.
No product in this corpus aims at NEDD9 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA NEDD9: RNA low tissue specificity; no normal tissue stained high; highest cancer staining lymphoma (6 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas NEDD9 tissue; Open Targets ENSG00000111859 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Law S.F. et al, Mol. Cell. Biol, 1996, "Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae". Source.
Sources: HGNC HGNC:7733 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14511 (protein name, function text, keywords and locations (REST API)); CIViC gene NEDD9 (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form. Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs. Plays a role in the organisation of T-cell F-actin cortical cytoskeleton and the centralisation of T-cell receptor microclusters at the immunological synapse. Location: Cytoplasm, cell cortex; Nucleus; Golgi apparatus; Cell projection, lamellipodium (UniProt). Locus 6p24.2 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: breast cancer, cervical cancer, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NEDD9" OR ABSTRACT:"NEDD9" OR TITLE:"neural precursor cell expressed, developmentally down-regulated 9" OR ABSTRACT:"neural precursor cell expressed, developmentally down-regulated 9" OR TITLE:"Enhancer of filamentation 1" OR ABSTRACT:"Enhancer of filamentation 1" OR TITLE:"HEF1" OR ABSTRACT:"HEF1" OR TITLE:"CAS-L" OR ABSTRACT:"CAS-L" OR TITLE:"CASS2" OR ABSTRACT:"CASS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NEDD9, not a curated reading list.