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NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes clinical 0.67, genetic literature 0.61, literature 0.93, genetic association 0.59, animal model 0.38).
In plain words · NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.
No product in this corpus aims at NDUFA13 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists NDUFA13 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA NDUFA13: RNA low tissue specificity; high antibody staining in 31 normal tissues; highest cancer staining endometrial cancer (6 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas NDUFA13 tissue; Open Targets ENSG00000186010 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Angell J.E. et al, J. Biol. Chem, 2000, "Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach". Source.
Sources: HGNC HGNC:17194 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P0J0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186010 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. Location: Mitochondrion inner membrane; Nucleus (UniProt). Locus 19p13.11 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Bone marrow, Bronchus, Cervix, Fallopian tube, Nasopharynx, Oral mucosa, Placenta, Rectum.
Medium only: breast cancer, carcinoid, glioma, head and neck cancer.
HPA NDUFA13 tissue · HPA NDUFA13 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"NDUFA13" OR ABSTRACT:"NDUFA13" OR TITLE:"NADH:ubiquinone oxidoreductase subunit A13" OR ABSTRACT:"NADH:ubiquinone oxidoreductase subunit A13" OR TITLE:"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13" OR ABSTRACT:"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13" OR TITLE:"CGI-39" OR ABSTRACT:"CGI-39" OR TITLE:"CDA016" OR ABSTRACT:"CDA016" OR TITLE:"GRIM-19" OR ABSTRACT:"GRIM-19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NDUFA13, not a curated reading list.