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NCOA1 (Nuclear receptor coactivator 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, animal model 0.44, genetic association 0.47, somatic mutation 0.59). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Pancreatic Adenocarcinoma.
In plain words · NCOA1 (Nuclear receptor coactivator 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
NCOA1 (Nuclear receptor coactivator 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.
No product in this corpus aims at NCOA1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Onate S.A. et al, Science, 1995, "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Source.
Sources: HGNC HGNC:7668 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15788 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000084676 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0)); IntOGen NCOA1 (driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Location: Nucleus (UniProt). Locus 2p23.3 (HGNC).
Query for this target: (TITLE:"NCOA1" OR ABSTRACT:"NCOA1" OR TITLE:"nuclear receptor coactivator 1" OR ABSTRACT:"nuclear receptor coactivator 1" OR TITLE:"Nuclear receptor coactivator 1" OR ABSTRACT:"Nuclear receptor coactivator 1" OR TITLE:"SRC1" OR ABSTRACT:"SRC1" OR TITLE:"F-SRC-1" OR ABSTRACT:"F-SRC-1" OR TITLE:"NCoA-1" OR ABSTRACT:"NCoA-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOA1, not a curated reading list.