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NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.43, genetic literature 0.76).
In plain words · NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis.
No product in this corpus aims at NAF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:25126 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96HR8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145414 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Location: Cytoplasm; Nucleus (UniProt). Locus 4q32.2 (HGNC).
Query for this target: (TITLE:"NAF1" OR ABSTRACT:"NAF1" OR TITLE:"nuclear assembly factor 1 ribonucleoprotein" OR ABSTRACT:"nuclear assembly factor 1 ribonucleoprotein" OR TITLE:"H/ACA ribonucleoprotein complex non-core subunit NAF1" OR ABSTRACT:"H/ACA ribonucleoprotein complex non-core subunit NAF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NAF1, not a curated reading list.