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NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.54, genetic association 0.00, somatic mutation 0.89).
In plain words · NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
No product in this corpus aims at NAB2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Svaren et al, Mol. Cell. Biol, 1996, "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Source.
Sources: HGNC HGNC:7627 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15742 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166886 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Location: Nucleus (UniProt). Locus 12q13.3 (HGNC).
Query for this target: (TITLE:"NAB2" OR ABSTRACT:"NAB2" OR TITLE:"NGFI-A binding protein 2" OR ABSTRACT:"NGFI-A binding protein 2" OR TITLE:"NGFI-A-binding protein 2" OR ABSTRACT:"NGFI-A-binding protein 2" OR TITLE:"MADER" OR ABSTRACT:"MADER") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NAB2, not a curated reading list.