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N4BP2 (NEDD4-binding protein 2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Bladder & urothelial cancer and Biliary tract cancer.
Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.
IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Cholangiocarcinoma, Hepatocellular Carcinoma, Upper Tract Urothelial Carcinoma.
In plain words · N4BP2 (NEDD4-binding protein 2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Bladder & urothelial cancer and Biliary tract cancer.
N4BP2 (NEDD4-binding protein 2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Bladder & urothelial cancer and Biliary tract cancer.
Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
No product in this corpus aims at N4BP2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:29851 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86UW6 (protein name, function text, keywords and locations (REST API)); IntOGen N4BP2 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon. Location: Cytoplasm (UniProt). Locus 4p14 (HGNC).
Query for this target: (TITLE:"N4BP2" OR ABSTRACT:"N4BP2" OR TITLE:"NEDD4 binding protein 2" OR ABSTRACT:"NEDD4 binding protein 2" OR TITLE:"NEDD4-binding protein 2" OR ABSTRACT:"NEDD4-binding protein 2" OR TITLE:"B3BP" OR ABSTRACT:"B3BP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about N4BP2, not a curated reading list.