{"entity":{"id":"n4bp2","kind":"target","name":"N4BP2","aka":["NEDD4 binding protein 2","NEDD4-binding protein 2","B3BP"],"tldr":"N4BP2 (NEDD4-binding protein 2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Bladder & urothelial cancer and Biliary tract cancer.","summary":"Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.\n\nIntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Cholangiocarcinoma, Hepatocellular Carcinoma, Upper Tract Urothelial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29851","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29851"},{"label":"UniProt Q86UW6","url":"https://www.uniprot.org/uniprotkb/Q86UW6/entry"},{"label":"NCBI Gene 55728","url":"https://www.ncbi.nlm.nih.gov/gene/55728"},{"label":"Ensembl ENSG00000078177","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078177"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["hcc","urothelial","cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"N4BP2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29851","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29851","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86UW6","url":"https://www.uniprot.org/uniprotkb/Q86UW6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen N4BP2","url":"https://www.intogen.org/search?gene=N4BP2","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:29851","ensembl":"ENSG00000078177","uniprot":"Q86UW6","entrez":"55728","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10718198/","biology":"Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon. Location: Cytoplasm (UniProt). Locus 4p14 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)","Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/n4bp2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}