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MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
UniProt has no function text for Q96EZ4; HGNC names it "myeloma overexpressed".
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.62, somatic mutation 0.23). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.
In plain words · MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.
UniProt has no function text for Q96EZ4; HGNC names it "myeloma overexpressed". Locus 11q13.3 (HGNC).
No product in this corpus aims at MYEOV yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2000. Earliest sequence paper UniProt cites for the protein: Janssen J.W.G. et al, Blood, 2000, "Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32)". Source.
Sources: HGNC HGNC:7563 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EZ4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000172927 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0)); IntOGen MYEOV (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q96EZ4; HGNC names it "myeloma overexpressed". Locus 11q13.3 (HGNC).
Query for this target: (TITLE:"MYEOV" OR ABSTRACT:"MYEOV" OR TITLE:"myeloma overexpressed" OR ABSTRACT:"myeloma overexpressed" OR TITLE:"Myeloma-overexpressed gene protein" OR ABSTRACT:"Myeloma-overexpressed gene protein") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYEOV, not a curated reading list.