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MX2 (Interferon-induced GTP-binding protein Mx2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Melanoma.
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd).
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.49, animal model 0.41, genetic association 0.66).
In plain words · MX2 (Interferon-induced GTP-binding protein Mx2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Melanoma.
MX2 (Interferon-induced GTP-binding protein Mx2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Melanoma.
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1).
No product in this corpus aims at MX2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1989. Earliest sequence paper UniProt cites for the protein: Aebi et al, Mol. Cell. Biol, 1989, "cDNA structures and regulation of two interferon-induced human Mx proteins". Source.
Sources: HGNC HGNC:7533 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P20592 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000183486 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: melanoma 0.54, skin cancer 0.50 (GraphQL API, CC0))
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. Location: Cytoplasm; Nucleus; Nucleus, nuclear pore complex (UniProt). Locus 21q22.3 (HGNC).
Query for this target: (TITLE:"MX2" OR ABSTRACT:"MX2" OR TITLE:"MX dynamin like GTPase 2" OR ABSTRACT:"MX dynamin like GTPase 2" OR TITLE:"Interferon-induced GTP-binding protein Mx2" OR ABSTRACT:"Interferon-induced GTP-binding protein Mx2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MX2, not a curated reading list.