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MT-ND1 (NADH-ubiquinone oxidoreductase chain 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.55, clinical 0.67).
In plain words · MT-ND1 (NADH-ubiquinone oxidoreductase chain 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
MT-ND1 (NADH-ubiquinone oxidoreductase chain 1) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
No product in this corpus aims at MT-ND1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MT-ND1: RNA tissue enhanced (heart muscle 129,323 nTPM); blood lineage lineage enriched (granulocytes 9,528 nTPM); high antibody staining in 3 normal tissues; highest cancer staining melanoma (2 of 10 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas MT-ND1 tissue; Open Targets ENSG00000198888 associations
First described 1980. Earliest sequence paper UniProt cites for the protein: Sanger et al, J. Mol. Biol, 1980, "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing". Source.
Sources: HGNC HGNC:7455 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P03886 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198888 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).
RNA: tissue enhanced (heart muscle 129,323 nTPM), detected in all normal tissues. Blood: lineage enriched (granulocytes 9,528 nTPM).
Medium: Appendix, Caudate, Cerebellum, Colon, Duodenum, Endometrium, Gallbladder, Hippocampus.
Medium only: breast cancer, carcinoid, cervical cancer, colorectal cancer.
HPA MT-ND1 tissue · HPA MT-ND1 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MT-ND1" OR ABSTRACT:"MT-ND1" OR TITLE:"mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1" OR ABSTRACT:"mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1" OR TITLE:"NADH-ubiquinone oxidoreductase chain 1" OR ABSTRACT:"NADH-ubiquinone oxidoreductase chain 1" OR TITLE:"ND1" OR ABSTRACT:"ND1" OR TITLE:"NAD1" OR ABSTRACT:"NAD1" OR TITLE:"MTND1" OR ABSTRACT:"MTND1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MT-ND1, not a curated reading list.