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MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.29, genetic association 0.84).
In plain words · MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.
No product in this corpus aims at MT-CYB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1981. Earliest sequence paper UniProt cites for the protein: Anderson et al, Nature, 1981, "Sequence and organization of the human mitochondrial genome". Source.
Sources: HGNC HGNC:7427 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P00156 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198727 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).
Query for this target: (TITLE:"MT-CYB" OR ABSTRACT:"MT-CYB" OR TITLE:"mitochondrially encoded cytochrome b" OR ABSTRACT:"mitochondrially encoded cytochrome b" OR TITLE:"Cytochrome b" OR ABSTRACT:"Cytochrome b" OR TITLE:"UQCR3" OR ABSTRACT:"UQCR3" OR TITLE:"MTCYB" OR ABSTRACT:"MTCYB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MT-CYB, not a curated reading list.