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MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.73, genetic literature 0.30).
In plain words · MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
No product in this corpus aims at MSR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1990. Earliest sequence paper UniProt cites for the protein: Matsumoto et al, Proc. Natl. Acad. Sci. U.S.A, 1990, "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions". Source.
Sources: HGNC HGNC:7376 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P21757 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000038945 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense. Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signalling. Does not internalise acetylated LDL. Location: Cell membrane (UniProt). Locus 8p22 (HGNC).
Query for this target: (TITLE:"MSR1" OR ABSTRACT:"MSR1" OR TITLE:"macrophage scavenger receptor 1" OR ABSTRACT:"macrophage scavenger receptor 1" OR TITLE:"Macrophage scavenger receptor types I and II" OR ABSTRACT:"Macrophage scavenger receptor types I and II" OR TITLE:"SCARA1" OR ABSTRACT:"SCARA1" OR TITLE:"CD204" OR ABSTRACT:"CD204" OR TITLE:"SR-AI" OR ABSTRACT:"SR-AI") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MSR1, not a curated reading list.