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MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.52, somatic mutation 0.98).
In plain words · MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.
MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.
No product in this corpus aims at MRTFA yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Dunham et al, Nature, 1999, "The DNA sequence of human chromosome 22". Source.
Sources: HGNC HGNC:14334 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q969V6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196588 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.54, breast cancer 0.62, lung cancer 0.52 (GraphQL API, CC0))
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1-q13.2 (HGNC).
Query for this target: (TITLE:"MRTFA" OR ABSTRACT:"MRTFA" OR TITLE:"myocardin related transcription factor A" OR ABSTRACT:"myocardin related transcription factor A" OR TITLE:"Myocardin-related transcription factor A" OR ABSTRACT:"Myocardin-related transcription factor A" OR TITLE:"KIAA1438" OR ABSTRACT:"KIAA1438" OR TITLE:"MRTF-A" OR ABSTRACT:"MRTF-A" OR TITLE:"MKL1" OR ABSTRACT:"MKL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MRTFA, not a curated reading list.