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MPEG1 (Macrophage-expressed gene 1 protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · MPEG1 (Macrophage-expressed gene 1 protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
MPEG1 (Macrophage-expressed gene 1 protein) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Pore-forming protein involved in both innate and adaptive immunity.
No product in this corpus aims at MPEG1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MPEG1: RNA tissue enhanced (lymphoid tissue 194 nTPM); blood lineage group enriched (dendritic cells 205 nTPM, monocytes 289 nTPM); no normal tissue stained high; highest cancer staining thyroid cancer (1 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas MPEG1 tissue; Open Targets ENSG00000197629 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:29619 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q2M385 (protein name, function text, keywords and locations (REST API)); CIViC gene MPEG1 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Location: Cytoplasmic vesicle membrane; Cytoplasmic vesicle, phagosome membrane; Secreted (UniProt). Locus 11q12.1 (HGNC).
RNA: tissue enhanced (lymphoid tissue 194 nTPM), detected in many normal tissues. Blood: group enriched (dendritic cells 205 nTPM, monocytes 289 nTPM).
No normal tissue stained high; medium in Adipose tissue, Adrenal gland, Appendix, Bone marrow, Breast, Bronchus and more.
Medium only: breast cancer, cervical cancer, colorectal cancer, glioma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MPEG1" OR ABSTRACT:"MPEG1" OR TITLE:"macrophage expressed 1" OR ABSTRACT:"macrophage expressed 1" OR TITLE:"Macrophage-expressed gene 1 protein" OR ABSTRACT:"Macrophage-expressed gene 1 protein" OR TITLE:"P2" OR ABSTRACT:"P2" OR TITLE:"MPS-1" OR ABSTRACT:"MPS-1" OR TITLE:"MPG1" OR ABSTRACT:"MPG1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MPEG1, not a curated reading list.