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MOV10 (RNA helicase MOV-10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
5'-3' RNA helicase. Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.76, animal model 0.29, genetic association 0.32).
In plain words · MOV10 (RNA helicase MOV-10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
MOV10 (RNA helicase MOV-10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
5'-3' RNA helicase. Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission.
No product in this corpus aims at MOV10 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:7200 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HCE1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000155363 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
5'-3' RNA helicase. Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. Location: Cytoplasm, P-body; Cytoplasm, Cytoplasmic ribonucleoprotein granule; Cytoplasm, Stress granule; Nucleus (UniProt). Locus 1p13.2 (HGNC).
Query for this target: (TITLE:"MOV10" OR ABSTRACT:"MOV10" OR TITLE:"Mov10 RNA helicase" OR ABSTRACT:"Mov10 RNA helicase" OR TITLE:"RNA helicase MOV-10" OR ABSTRACT:"RNA helicase MOV-10" OR TITLE:"gb110" OR ABSTRACT:"gb110" OR TITLE:"MGC2948" OR ABSTRACT:"MGC2948" OR TITLE:"fSAP113" OR ABSTRACT:"fSAP113") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MOV10, not a curated reading list.