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MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.64).
In plain words · MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
No product in this corpus aims at MLPH yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:29643 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BV36 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115648 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Location: Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
Query for this target: (TITLE:"MLPH" OR ABSTRACT:"MLPH" OR TITLE:"melanophilin" OR ABSTRACT:"melanophilin" OR TITLE:"Melanophilin" OR ABSTRACT:"Melanophilin" OR TITLE:"l1Rk3" OR ABSTRACT:"l1Rk3" OR TITLE:"l 1 -3Rk" OR ABSTRACT:"l 1 -3Rk" OR TITLE:"Slac-2a" OR ABSTRACT:"Slac-2a") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLPH, not a curated reading list.