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MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.
Probably involved in the repair of mismatches in DNA.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.91, somatic mutation 0.55, genetic literature 0.49).
In plain words · MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.
MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt).
No product in this corpus aims at MLH3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Sherrington et al, Nature, 1995, "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Source.
Sources: HGNC HGNC:7128 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UHC1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000119684 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.68, endometrial cancer 0.53 (GraphQL API, CC0))
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 14q24.3 (HGNC).
Query for this target: (TITLE:"MLH3" OR ABSTRACT:"MLH3" OR TITLE:"mutL homolog 3" OR ABSTRACT:"mutL homolog 3" OR TITLE:"DNA mismatch repair protein Mlh3" OR ABSTRACT:"DNA mismatch repair protein Mlh3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLH3, not a curated reading list.