Loading
MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.
Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.49, genetic association 0.00, somatic mutation 0.97).
In plain words · MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.
MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.
Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation.
No product in this corpus aims at MLF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Yoneda-Kato et al, Oncogene, 1996, "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Source.
Sources: HGNC HGNC:7125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P58340 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178053 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: lung cancer 0.52 (GraphQL API, CC0))
Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Location: Cytoplasm; Nucleus; Cell projection, cilium; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 3q25.32 (HGNC).
Query for this target: (TITLE:"MLF1" OR ABSTRACT:"MLF1" OR TITLE:"myeloid leukemia factor 1" OR ABSTRACT:"myeloid leukemia factor 1" OR TITLE:"Myeloid leukemia factor 1" OR ABSTRACT:"Myeloid leukemia factor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLF1, not a curated reading list.