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MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.97, genetic association 0.22).
In plain words · MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4.
No product in this corpus aims at MARK3 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1992. Earliest sequence paper UniProt cites for the protein: Maheshwari K.K. et al, 1992. Source.
Sources: HGNC HGNC:6897 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P27448 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000075413 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localisation and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localisation and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Location: Cell membrane; Cell projection, dendrite; Cytoplasm (UniProt). Locus 14q32.32-q32.33 (HGNC).
Query for this target: (TITLE:"MARK3" OR ABSTRACT:"MARK3" OR TITLE:"microtubule affinity regulating kinase 3" OR ABSTRACT:"microtubule affinity regulating kinase 3" OR TITLE:"MAP/microtubule affinity-regulating kinase 3" OR ABSTRACT:"MAP/microtubule affinity-regulating kinase 3" OR TITLE:"CTAK1" OR ABSTRACT:"CTAK1" OR TITLE:"KP78" OR ABSTRACT:"KP78" OR TITLE:"PAR-1A" OR ABSTRACT:"PAR-1A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MARK3, not a curated reading list.