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MAPK8 (Mitogen-activated protein kinase 8) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signalling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes clinical 0.06, affected pathway 0.89, literature 0.99, genetic association 0.00, animal model 0.51).
In plain words · MAPK8 (Mitogen-activated protein kinase 8) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
MAPK8 (Mitogen-activated protein kinase 8) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death.
No product in this corpus aims at MAPK8 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA MAPK8: RNA low tissue specificity; high antibody staining in 5 normal tissues; highest cancer staining cervical cancer (1 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas MAPK8 tissue; Open Targets ENSG00000107643 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Derijard et al, Cell, 1994, "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Source.
Sources: HGNC HGNC:6881 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P45983 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107643 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signalling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Location: Cytoplasm; Nucleus; Synapse (UniProt). Locus 10q11.22 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Bone marrow, Bronchus, Caudate, Cerebellum, Cerebral cortex, Duodenum, Endometrium.
Medium only: breast cancer, carcinoid, colorectal cancer, endometrial cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MAPK8" OR ABSTRACT:"MAPK8" OR TITLE:"mitogen-activated protein kinase 8" OR ABSTRACT:"mitogen-activated protein kinase 8" OR TITLE:"Mitogen-activated protein kinase 8" OR ABSTRACT:"Mitogen-activated protein kinase 8" OR TITLE:"JNK1" OR ABSTRACT:"JNK1" OR TITLE:"SAPK1" OR ABSTRACT:"SAPK1" OR TITLE:"PRKM8" OR ABSTRACT:"PRKM8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAPK8, not a curated reading list.