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MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes affected pathway 0.94, literature 0.12, genetic association 0.00, somatic mutation 0.23, animal model 0.35).
In plain words · MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.
No product in this corpus aims at MAMLD1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Laporte et al, Nat. Genet, 1996, "A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast". Source.
Sources: HGNC HGNC:2568 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13495 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000013619 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. Location: Nucleus (UniProt). Locus Xq28 (HGNC).
Query for this target: (TITLE:"MAMLD1" OR ABSTRACT:"MAMLD1" OR TITLE:"mastermind like domain containing 1" OR ABSTRACT:"mastermind like domain containing 1" OR TITLE:"Mastermind-like domain-containing protein 1" OR ABSTRACT:"Mastermind-like domain-containing protein 1" OR TITLE:"CG1" OR ABSTRACT:"CG1" OR TITLE:"F18" OR ABSTRACT:"F18" OR TITLE:"CXorf6" OR ABSTRACT:"CXorf6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAMLD1, not a curated reading list.