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MAML3 (Mastermind-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.30, affected pathway 0.94, genetic association 0.56).
In plain words · MAML3 (Mastermind-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
MAML3 (Mastermind-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
No product in this corpus aims at MAML3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2001. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:16272 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96JK9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196782 (association with cancer (MONDO_0004992) 0.68; (GraphQL API, CC0))
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Location: Nucleus speckle (UniProt). Locus 4q31.1 (HGNC).
Query for this target: (TITLE:"MAML3" OR ABSTRACT:"MAML3" OR TITLE:"mastermind like transcriptional coactivator 3" OR ABSTRACT:"mastermind like transcriptional coactivator 3" OR TITLE:"Mastermind-like protein 3" OR ABSTRACT:"Mastermind-like protein 3" OR TITLE:"KIAA1816" OR ABSTRACT:"KIAA1816" OR TITLE:"MAM2" OR ABSTRACT:"MAM2" OR TITLE:"CAGH3" OR ABSTRACT:"CAGH3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAML3, not a curated reading list.