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MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.89, animal model 0.26, genetic association 0.27, somatic mutation 0.93).
In plain words · MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells.
No product in this corpus aims at MAFB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Wang P.W. et al, Genomics, 1999, "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias". Source.
Sources: HGNC HGNC:6408 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5Q3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204103 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.50 (GraphQL API, CC0))
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. Location: Nucleus (UniProt). Locus 20q12 (HGNC).
Query for this target: (TITLE:"MAFB" OR ABSTRACT:"MAFB" OR TITLE:"MAF bZIP transcription factor B" OR ABSTRACT:"MAF bZIP transcription factor B" OR TITLE:"Transcription factor MafB" OR ABSTRACT:"Transcription factor MafB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAFB, not a curated reading list.