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MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.
Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fibre cell differentiation.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes affected pathway 0.38, literature 0.82, genetic association 0.54, somatic mutation 0.81, animal model 0.76). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.
In plain words · MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.
MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.
Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development.
No product in this corpus aims at MAF yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Chesi et al, Blood, 1998, "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma". Source.
Sources: HGNC HGNC:6776 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75444 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178573 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.59 (GraphQL API, CC0)); IntOGen MAF (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fibre cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Location: Nucleus (UniProt). Locus 16q23.2 (HGNC).
Query for this target: (TITLE:"MAF" OR ABSTRACT:"MAF" OR TITLE:"MAF bZIP transcription factor" OR ABSTRACT:"MAF bZIP transcription factor" OR TITLE:"Transcription factor Maf" OR ABSTRACT:"Transcription factor Maf" OR TITLE:"c-MAF" OR ABSTRACT:"c-MAF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAF, not a curated reading list.