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LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.76, animal model 0.49, genetic association 0.15, somatic mutation 0.94).
In plain words · LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes. Location: Nucleus (UniProt).
No product in this corpus aims at LYL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Mellentin J.D. et al, Cell, 1989, "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Source.
Sources: HGNC HGNC:6734 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12980 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104903 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes. Location: Nucleus (UniProt). Locus 19p13.13 (HGNC).
Query for this target: (TITLE:"LYL1" OR ABSTRACT:"LYL1" OR TITLE:"LYL1 basic helix-loop-helix family member" OR ABSTRACT:"LYL1 basic helix-loop-helix family member" OR TITLE:"bHLHa18" OR ABSTRACT:"bHLHa18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LYL1, not a curated reading list.