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LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signalling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.91, affected pathway 0.83, animal model 0.60, genetic association 0.00).
In plain words · LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins.
No product in this corpus aims at LRP5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Dong et al, Biochem. Biophys. Res. Commun, 1998, "Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity". Source.
Sources: HGNC HGNC:6697 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75197 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162337 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signalling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signalling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilising beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Location: Membrane; Endoplasmic reticulum (UniProt). Locus 11q13.2 (HGNC).
Query for this target: (TITLE:"LRP5" OR ABSTRACT:"LRP5" OR TITLE:"LDL receptor related protein 5" OR ABSTRACT:"LDL receptor related protein 5" OR TITLE:"Low-density lipoprotein receptor-related protein 5" OR ABSTRACT:"Low-density lipoprotein receptor-related protein 5" OR TITLE:"LR3" OR ABSTRACT:"LR3" OR TITLE:"BMND1" OR ABSTRACT:"BMND1" OR TITLE:"OPTA1" OR ABSTRACT:"OPTA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRP5, not a curated reading list.
Shares Wnt / β-catenin, Open Targets Platform.
Shares Wnt / β-catenin, Open Targets Platform.
Shares Wnt / β-catenin, Open Targets Platform.
Shares Wnt / β-catenin, Open Targets Platform.
Shares Wnt / β-catenin, Open Targets Platform.
Shares Wnt / β-catenin, Open Targets Platform.
Shares Wnt / β-catenin, Open Targets Platform.