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LPA (Apolipoprotein(a)) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.63, somatic mutation 0.37). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
In plain words · LPA (Apolipoprotein(a)) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
LPA (Apolipoprotein(a)) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis.
No product in this corpus aims at LPA yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1987. Earliest sequence paper UniProt cites for the protein: McLean J.W. et al, Nature, 1987, "cDNA sequence of human apolipoprotein(a) is homologous to plasminogen". Source.
Sources: HGNC HGNC:6667 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08519 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198670 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0)); IntOGen LPA (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Locus 6q25.3-q26 (HGNC).
Query for this target: (TITLE:"LPA" OR ABSTRACT:"LPA" OR TITLE:"lipoprotein a" OR ABSTRACT:"lipoprotein a" OR TITLE:"Apolipoprotein a" OR ABSTRACT:"Apolipoprotein a" OR TITLE:"Lp a" OR ABSTRACT:"Lp a") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LPA, not a curated reading list.