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LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.80, animal model 0.69, genetic association 0.62).
In plain words · LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
No product in this corpus aims at LMX1B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1998. Earliest sequence paper UniProt cites for the protein: Vollrath et al, Hum. Mol. Genet, 1998, "Loss-of-function mutations in the LIM-homeodomain gene, LMX1B, in nail-patella syndrome". Source.
Sources: HGNC HGNC:6654 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60663 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136944 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Location: Nucleus (UniProt). Locus 9q33.3 (HGNC).
Query for this target: (TITLE:"LMX1B" OR ABSTRACT:"LMX1B" OR TITLE:"LIM homeobox transcription factor 1 beta" OR ABSTRACT:"LIM homeobox transcription factor 1 beta" OR TITLE:"LIM homeobox transcription factor 1-beta" OR ABSTRACT:"LIM homeobox transcription factor 1-beta" OR TITLE:"NPS1" OR ABSTRACT:"NPS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMX1B, not a curated reading list.