Loading
LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes affected pathway 0.35, literature 0.93, genetic association 0.03, somatic mutation 0.96, animal model 0.52).
In plain words · LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
No product in this corpus aims at LMO2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1991. Earliest sequence paper UniProt cites for the protein: Royer-Pokora et al, Oncogene, 1991, "TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)". Source.
Sources: HGNC HGNC:6642 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25791 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135363 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0))
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. Location: Nucleus (UniProt). Locus 11p13 (HGNC).
Query for this target: (TITLE:"LMO2" OR ABSTRACT:"LMO2" OR TITLE:"LIM domain only 2" OR ABSTRACT:"LIM domain only 2" OR TITLE:"Rhombotin-2" OR ABSTRACT:"Rhombotin-2" OR TITLE:"TTG2" OR ABSTRACT:"TTG2" OR TITLE:"RHOM2" OR ABSTRACT:"RHOM2" OR TITLE:"RBTN2" OR ABSTRACT:"RBTN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMO2, not a curated reading list.