Loading
LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.37, somatic mutation 0.96).
In plain words · LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Location: Nucleus (UniProt).
No product in this corpus aims at LMO1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1989. Earliest sequence paper UniProt cites for the protein: McGuire E.A. et al, Mol. Cell. Biol, 1989, "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein". Source.
Sources: HGNC HGNC:6641 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25800 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166407 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.51 (GraphQL API, CC0))
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Location: Nucleus (UniProt). Locus 11p15.4 (HGNC).
Query for this target: (TITLE:"LMO1" OR ABSTRACT:"LMO1" OR TITLE:"LIM domain only 1" OR ABSTRACT:"LIM domain only 1" OR TITLE:"Rhombotin-1" OR ABSTRACT:"Rhombotin-1" OR TITLE:"TTG1" OR ABSTRACT:"TTG1" OR TITLE:"RHOM1" OR ABSTRACT:"RHOM1" OR TITLE:"RBTN1" OR ABSTRACT:"RBTN1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMO1, not a curated reading list.