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LMNA (Prelamin-A/C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organisation, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.88, genetic association 0.33, somatic mutation 0.49, animal model 0.61).
In plain words · LMNA (Prelamin-A/C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
LMNA (Prelamin-A/C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane.
No product in this corpus aims at LMNA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1986. Earliest sequence paper UniProt cites for the protein: McKeon F.D. et al, Nature, 1986, "Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins". Source.
Sources: HGNC HGNC:6636 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02545 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000160789 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organisation, nuclear membrane and telomere dynamics. Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. Lamin A and C are present in equal amounts in the lamina of mammals. Also involved in DNA repair: recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilising broken DNA ends. Location: Nucleus lamina; Nucleus envelope; Nucleus, nucleoplasm; Nucleus matrix (UniProt). Locus 1q22 (HGNC).
Query for this target: (TITLE:"LMNA" OR ABSTRACT:"LMNA" OR TITLE:"lamin A/C" OR ABSTRACT:"lamin A/C" OR TITLE:"Prelamin-A/C" OR ABSTRACT:"Prelamin-A/C" OR TITLE:"LMN1" OR ABSTRACT:"LMN1" OR TITLE:"CMD1A" OR ABSTRACT:"CMD1A" OR TITLE:"LGMD1B" OR ABSTRACT:"LGMD1B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LMNA, not a curated reading list.