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LAMA5 (Laminin subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signalling and PTK2B/PYK2.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.89, animal model 0.44, genetic association 0.64, somatic mutation 0.23).
In plain words · LAMA5 (Laminin subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
LAMA5 (Laminin subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components.
No product in this corpus aims at LAMA5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Durkin M.E. et al, FEBS Lett, 1997, "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation". Source.
Sources: HGNC HGNC:6485 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15230 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000130702 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signalling and PTK2B/PYK2. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 20q13.33 (HGNC).
Query for this target: (TITLE:"LAMA5" OR ABSTRACT:"LAMA5" OR TITLE:"laminin subunit alpha 5" OR ABSTRACT:"laminin subunit alpha 5" OR TITLE:"Laminin subunit alpha-5" OR ABSTRACT:"Laminin subunit alpha-5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LAMA5, not a curated reading list.