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KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.03, somatic mutation 0.92).
In plain words · KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
No product in this corpus aims at KTN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Print C.G. et al, Gene, 1994, "Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats". Source.
Sources: HGNC HGNC:6467 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86UP2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126777 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Location: Endoplasmic reticulum membrane (UniProt). Locus 14q22.3 (HGNC).
Query for this target: (TITLE:"KTN1" OR ABSTRACT:"KTN1" OR TITLE:"kinectin 1" OR ABSTRACT:"kinectin 1" OR TITLE:"Kinectin" OR ABSTRACT:"Kinectin" OR TITLE:"KIAA0004" OR ABSTRACT:"KIAA0004" OR TITLE:"CG1" OR ABSTRACT:"CG1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KTN1, not a curated reading list.