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KSR2 (Kinase suppressor of Ras 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.97, genetic association 0.47).
In plain words · KSR2 (Kinase suppressor of Ras 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
KSR2 (Kinase suppressor of Ras 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro).
No product in this corpus aims at KSR2 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 2003. Earliest sequence paper UniProt cites for the protein: Channavajhala P.L. et al, J. Biol. Chem, 2003, "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". Source.
Sources: HGNC HGNC:18610 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6VAB6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171435 (association with cancer (MONDO_0004992) 0.69; (GraphQL API, CC0))
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signalling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Location: Cytoplasm; Membrane (UniProt). Locus 12q24.22-q24.23 (HGNC).
Query for this target: (TITLE:"KSR2" OR ABSTRACT:"KSR2" OR TITLE:"kinase suppressor of ras 2" OR ABSTRACT:"kinase suppressor of ras 2" OR TITLE:"Kinase suppressor of Ras 2" OR ABSTRACT:"Kinase suppressor of Ras 2" OR TITLE:"FLJ25965" OR ABSTRACT:"FLJ25965") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KSR2, not a curated reading list.