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KSR1 (Kinase suppressor of Ras 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Part of a multiprotein signalling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.97, animal model 0.57, genetic association 0.00).
In plain words · KSR1 (Kinase suppressor of Ras 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
KSR1 (Kinase suppressor of Ras 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.
Part of a multiprotein signalling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases.
No product in this corpus aims at KSR1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1995. Earliest sequence paper UniProt cites for the protein: Therrien et al, Cell, 1995, "KSR, a novel protein kinase required for RAS signal transduction". Source.
Sources: HGNC HGNC:6465 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IVT5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141068 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Part of a multiprotein signalling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. Location: Cytoplasm; Membrane; Cell membrane; Cell projection, ruffle membrane (UniProt). Locus 17q11.2 (HGNC).
Query for this target: (TITLE:"KSR1" OR ABSTRACT:"KSR1" OR TITLE:"kinase suppressor of ras 1" OR ABSTRACT:"kinase suppressor of ras 1" OR TITLE:"Kinase suppressor of Ras 1" OR ABSTRACT:"Kinase suppressor of Ras 1" OR TITLE:"RSU2" OR ABSTRACT:"RSU2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KSR1, not a curated reading list.