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KRT18 (Keratin, type I cytoskeletal 18) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Structural component of intermediate filaments in simple epithelial cells. Forms intermediate filaments by heterodimerising with the type II keratin KRT8, providing mechanical stability and resilience to epithelial cells. Involved in ARHGEF40-mediated actin stress fibre formation and tensional force-induced stress fibre formation and reinforcement.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · KRT18 (Keratin, type I cytoskeletal 18) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
KRT18 (Keratin, type I cytoskeletal 18) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Structural component of intermediate filaments in simple epithelial cells. Forms intermediate filaments by heterodimerising with the type II keratin KRT8, providing mechanical stability and resilience to epithelial cells.
No product in this corpus aims at KRT18 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA KRT18: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 77 nTPM); high antibody staining in 24 normal tissues; highest cancer staining pancreatic cancer (12 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas KRT18 tissue; Open Targets ENSG00000111057 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Oshima R.G. et al, Differentiation, 1986, "Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation". Source.
Sources: HGNC HGNC:6430 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P05783 (protein name, function text, keywords and locations (REST API)); CIViC gene KRT18 (1 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0))
Structural component of intermediate filaments in simple epithelial cells. Forms intermediate filaments by heterodimerising with the type II keratin KRT8, providing mechanical stability and resilience to epithelial cells. Involved in ARHGEF40-mediated actin stress fibre formation and tensional force-induced stress fibre formation and reinforcement. Integrates into the intermediate filament network of skeletal muscle fibres alongside desmin and KRT19, contributing to force transmission. Organisation and orientation of KRT8/KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules. Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading. Location: Nucleus matrix; Cytoplasm, perinuclear region; Nucleus, nucleolus; Cytoplasm (UniProt). Locus 12q13.13 (HGNC).
RNA: low tissue specificity, detected in many normal tissues. Blood: lineage enriched (granulocytes 77 nTPM).
Medium: Adrenal gland, Skin, Urinary bladder.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KRT18" OR ABSTRACT:"KRT18" OR TITLE:"keratin 18" OR ABSTRACT:"keratin 18" OR TITLE:"Keratin, type I cytoskeletal 18" OR ABSTRACT:"Keratin, type I cytoskeletal 18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KRT18, not a curated reading list.