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KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy.
In plain words · KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.
KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability.
No product in this corpus aims at KLHDC8B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Wan et al, Proc. Natl. Acad. Sci. U.S.A, 2004, "Large-scale cDNA transfection screening for genes related to cancer development and progression". Source.
Sources: HGNC HGNC:28557 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IXV7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000185909 (per-cancer scores at or above 0.5: Hodgkins lymphoma 0.55 (GraphQL API, CC0))
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Location: Cytoplasm; Midbody (UniProt). Locus 3p21.31 (HGNC).
Query for this target: (TITLE:"KLHDC8B" OR ABSTRACT:"KLHDC8B" OR TITLE:"kelch domain containing 8B" OR ABSTRACT:"kelch domain containing 8B" OR TITLE:"Kelch domain-containing protein 8B" OR ABSTRACT:"Kelch domain-containing protein 8B" OR TITLE:"MGC35097" OR ABSTRACT:"MGC35097") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLHDC8B, not a curated reading list.