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KLF6 (Krueppel-like factor 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Skin cancer and Melanoma.
Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development.
Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.24, somatic mutation 0.93, genetic literature 0.76). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.
In plain words · KLF6 (Krueppel-like factor 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Skin cancer and Melanoma.
KLF6 (Krueppel-like factor 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Skin cancer and Melanoma.
Transcriptional activator. Binds a GC box motif.
No product in this corpus aims at KLF6 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: El Rouby et al, Oncogene, 1996, "Identification of Bcd, a novel proto-oncogene expressed in B-cells". Source.
Sources: HGNC HGNC:2235 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99612 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000067082 (association with cancer (MONDO_0004992) 0.78; per-cancer scores at or above 0.5: prostate cancer 0.62, melanoma 0.58, skin cancer 0.53 (GraphQL API, CC0)); IntOGen KLF6 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development. Location: Nucleus (UniProt). Locus 10p15.2 (HGNC).
Query for this target: (TITLE:"KLF6" OR ABSTRACT:"KLF6" OR TITLE:"KLF transcription factor 6" OR ABSTRACT:"KLF transcription factor 6" OR TITLE:"Krueppel-like factor 6" OR ABSTRACT:"Krueppel-like factor 6" OR TITLE:"Zf9" OR ABSTRACT:"Zf9" OR TITLE:"PAC1" OR ABSTRACT:"PAC1" OR TITLE:"BCD1" OR ABSTRACT:"BCD1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLF6, not a curated reading list.