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KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.76, genetic association 0.38).
In plain words · KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
No product in this corpus aims at KLC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1993. Earliest sequence paper UniProt cites for the protein: Cabeza-Arvelaiz et al, DNA Cell Biol, 1993, "Cloning and genetic characterization of the human kinesin light-chain (KLC) gene". Source.
Sources: HGNC HGNC:6387 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q07866 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126214 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Location: Cell projection, growth cone; Cytoplasmic vesicle; Cytoplasm, cytoskeleton (UniProt). Locus 14q32.33 (HGNC).
Query for this target: (TITLE:"KLC1" OR ABSTRACT:"KLC1" OR TITLE:"kinesin light chain 1" OR ABSTRACT:"kinesin light chain 1" OR TITLE:"Kinesin light chain 1" OR ABSTRACT:"Kinesin light chain 1" OR TITLE:"KNS2A" OR ABSTRACT:"KNS2A" OR TITLE:"hKLC1S" OR ABSTRACT:"hKLC1S" OR TITLE:"hKLC1N" OR ABSTRACT:"hKLC1N") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLC1, not a curated reading list.