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KITLG (Kit ligand) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Testicular germ cell tumours.
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, haematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signalling pathways.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.61, animal model 0.55, genetic association 0.68).
In plain words · KITLG (Kit ligand) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Testicular germ cell tumours.
KITLG (Kit ligand) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Testicular germ cell tumours.
Ligand for the receptor-type protein-tyrosine kinase KIT.
No product in this corpus aims at KITLG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1990. Earliest sequence paper UniProt cites for the protein: Martin F.H. et al, Cell, 1990, "Primary structure and functional expression of rat and human stem cell factor DNAs". Source.
Sources: HGNC HGNC:6343 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P21583 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000049130 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: testicular cancer 0.51 (GraphQL API, CC0))
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, haematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signalling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. Location: Cell membrane; Cytoplasm; Cytoplasm, cytoskeleton; Cell projection, lamellipodium (UniProt). Locus 12q21.32 (HGNC).
Query for this target: (TITLE:"KITLG" OR ABSTRACT:"KITLG" OR TITLE:"KIT ligand" OR ABSTRACT:"KIT ligand" OR TITLE:"Kit ligand" OR ABSTRACT:"Kit ligand" OR TITLE:"Kitl" OR ABSTRACT:"Kitl" OR TITLE:"KL-1" OR ABSTRACT:"KL-1" OR TITLE:"FPH2" OR ABSTRACT:"FPH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KITLG, not a curated reading list.