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KDM7A (Lysine-specific demethylase 7A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.89, animal model 0.36, genetic association 0.68).
In plain words · KDM7A (Lysine-specific demethylase 7A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
KDM7A (Lysine-specific demethylase 7A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Histone demethylase required for brain development.
No product in this corpus aims at KDM7A yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:22224 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZMT4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000006459 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Location: Nucleus (UniProt). Locus 7q34 (HGNC).
Query for this target: (TITLE:"KDM7A" OR ABSTRACT:"KDM7A" OR TITLE:"lysine demethylase 7A" OR ABSTRACT:"lysine demethylase 7A" OR TITLE:"Lysine-specific demethylase 7A" OR ABSTRACT:"Lysine-specific demethylase 7A" OR TITLE:"KIAA1718" OR ABSTRACT:"KIAA1718" OR TITLE:"JHDM1D" OR ABSTRACT:"JHDM1D") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KDM7A, not a curated reading list.