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KCNF1 (Voltage-gated potassium channel regulatory subunit KCNF1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarisation and inactivation during maintained depolarisation. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.69, somatic mutation 0.23, clinical 0.76).
In plain words · KCNF1 (Voltage-gated potassium channel regulatory subunit KCNF1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
KCNF1 (Voltage-gated potassium channel regulatory subunit KCNF1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarisation and inactivation during maintained depolarisation.
No product in this corpus aims at KCNF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KCNF1: RNA group enriched (brain 45 nTPM, choroid plexus 24 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Lambert-Eaton myasthenic syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas KCNF1 tissue; Open Targets ENSG00000162975 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Su et al, Biochem. Biophys. Res. Commun, 1997, "Isolation, characterization, and mapping of two human potassium channels". Source.
Sources: HGNC HGNC:6246 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H3M0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162975 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarisation and inactivation during maintained depolarisation. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. Location: Cell membrane (UniProt). Locus 2p25.1 (HGNC).
RNA: group enriched (brain 45 nTPM, choroid plexus 24 nTPM), detected in some normal tissues.
Medium: Cerebral cortex.
RNA cancer enriched: Glioblastoma Multiforme 46 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KCNF1" OR ABSTRACT:"KCNF1" OR TITLE:"potassium voltage-gated channel modifier subfamily F member 1" OR ABSTRACT:"potassium voltage-gated channel modifier subfamily F member 1" OR TITLE:"Voltage-gated potassium channel regulatory subunit KCNF1" OR ABSTRACT:"Voltage-gated potassium channel regulatory subunit KCNF1" OR TITLE:"Kv5.1" OR ABSTRACT:"Kv5.1" OR TITLE:"kH1" OR ABSTRACT:"kH1" OR TITLE:"IK8" OR ABSTRACT:"IK8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNF1, not a curated reading list.