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KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.47, clinical 0.76).
In plain words · KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Mediates the voltage-dependent potassium ion permeability of excitable membranes.
No product in this corpus aims at KCNA3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KCNA3: RNA tissue enhanced (intestine 2 nTPM, lung 2 nTPM, lymphoid tissue 3 nTPM); blood lineage group enriched (B-cells 3 nTPM, T-cells 10 nTPM); no normal tissue stained high; highest cancer staining glioma (2 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Lambert-Eaton myasthenic syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas KCNA3 tissue; Open Targets ENSG00000177272 associations
First described 1991. Earliest sequence paper UniProt cites for the protein: Philipson L.H. et al, Proc. Natl. Acad. Sci. U.S.A, 1991, "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel". Source.
Sources: HGNC HGNC:6221 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P22001 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000177272 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Lacks voltage-gated potassium channel activity. Location: Cell membrane; Cytoplasm, perinuclear region (UniProt). Locus 1p13.3 (HGNC).
RNA: tissue enhanced (intestine 2 nTPM, lung 2 nTPM, lymphoid tissue 3 nTPM), detected in some normal tissues. Blood: group enriched (B-cells 3 nTPM, T-cells 10 nTPM).
No normal tissue stained high; medium in Caudate, Cerebellum, Cerebral cortex, Hippocampus.
Medium only: cervical cancer, liver cancer, ovarian cancer.
HPA KCNA3 tissue · HPA KCNA3 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"KCNA3" OR ABSTRACT:"KCNA3" OR TITLE:"potassium voltage-gated channel subfamily A member 3" OR ABSTRACT:"potassium voltage-gated channel subfamily A member 3" OR TITLE:"Potassium voltage-gated channel subfamily A member 3" OR ABSTRACT:"Potassium voltage-gated channel subfamily A member 3" OR TITLE:"Kv1.3" OR ABSTRACT:"Kv1.3" OR TITLE:"MK3" OR ABSTRACT:"MK3" OR TITLE:"HLK3" OR ABSTRACT:"HLK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KCNA3, not a curated reading list.